Amazing Spiderman Vol 1 Issue 361 GCG 6.5 (Signature Series)

1st full app Carnage in Savage Genesis! 

Blood runs in the streets as a serial killer roams New York City! And as the web-slinger investigates the murders, he notices a very disturbing similarity to another killer's modus operandi! In a burned-out building in Brooklyn, the spectacular one comes face-to-face with his new homicidal foe...Carnage! Can the wall-crawler end Cletus Kasady's rampage in their very first encounter? Cameo appearances by Aunt May and Mary Jane Watson. Flashback cameo by Venom.

Picture of actual comic book